Fri Dec 19 2025

113 articles - From Friday Dec 12 2025 to Friday Dec 19 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Am J Gastroenterol
Correction: ACG Clinical Guideline Ulcerative Colitis in Adults.

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Endosc Int Open
Lymph node metastases in early gastric cancer: Japanese Gastric Cancer Treatment Guidelines can be used for endoscopic resection in the West.

The eCura system for defining endoscopic curability could have been safely applied in this Western population. Even in Western countries, patients with early gastric cancer that meets Japanese guidelines for endoscopic resection should, where possible, undergo en bloc endoscopic submucosal dissection. Lesions classified histologically as eCuraA or B should be considered endoscopically cured.

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Gastroenterology
Multi-Society Expert Panel Consensus Guidance Regarding Clinical Assessment and Clinical Trial Endpoints in Adults with Alpha-1 Antitrypsin Deficiency-Associated Liver Disease (AATD-LD).

These consensus statements provide a unified framework for diagnosing, staging, and studying AATD-LD. Broad adoption will improve disease recognition, optimize clinical management, and facilitate therapeutic development.

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Hepatology
AASLD AST Practice Guideline on adult liver transplantation: Candidate evaluation.

Liver transplant is a lifesaving procedure that should be offered to selected patients with clear indications and a reasonable prospect of benefit. The evaluation is designed to identify those in need, to outline hurdles to a successful outcome, and to develop an effective transplant plan. The goal of this document is to provide a template for this process.

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Meta-analysis

meta-analyses and systematic reviews

Aliment Pharmacol Ther
Meta-Analysis: High anti-HBs Titers are Associated with Significantly Reduced Risk of Hepatitis B Virus Reactivation During Rituximab Treatment.

The search was conducted in PubMed, Embase via Elsevier, Scopus, and Cochrane CENTRAL inclusive July 2025. We evaluated the incidence of HBV reactivation from cohort studies that described anti-HBs categorically based on anti-HBs titer: 'negative' (titer 100 iU/L can be considered lower risk for HBV reactivation and may not require antiviral therapy, but monitoring with initiation of antiviral therapy if titer falls below 100 iU/L.

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Hepatology
Hepatocellular carcinoma with macrovascular invasion: Review and survival meta-analysis of initial local therapy using minimal prognostic criteria.

In HCC with MaVI, 1-year OS is the most comparable endpoint across modalities. This analysis identifies TARE as the only consistently reproducible option, showing a 1-year survival of 34%. In contrast, surgery and sequential therapies remain confounded by substantial heterogeneity. Accordingly, stratified head-to-head trials comparing alternative modalities against immunotherapy are warranted.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Gastroenterol
A PROSPECTIVE INTERVENTIONAL STUDY TO EVALUATE THE EFFECT OF HYPOXIA ON HEALTHY VOLUNTEERS AND PATIENTS WITH INFLAMMATORY BOWEL DISEASE: THE ALTITUDE IBD STUDY.

Low-pressure chamber exposure - although the primary outcome was not met - led to a flare in a third of UC patients, with changes in calprotectin levels and specific bacterial strains.

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Association of SGLT2 Inhibitors with Reduced Hepatocellular Carcinoma Risk in Patients with Type 2 Diabetes.

SGLT2 inhibitor therapy was associated with reduced risk of HCC compared with DPP4 inhibitors and sulfonylureas, supporting their potential chemopreventive role in patients with T2DM.

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Budd Chiari Syndrome: Presentation, Management, and Prognosis.

There are limited data on chronic BCS and these patients are often diagnosed with complications of postal hypertension or liver cancer. In this review, we discuss our current understanding of etiologies, diagnostic options and prognostic scores, natural history including pregnancy outcomes, and treatment outcomes of BCS.

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Enhancing Patient Empowerment through Artificial Intelligence in Liver Cancer.

Key concerns are related to ethical considerations, regulation, data privacy, transparency, algorithmic bias, rigorous clinical validation and patient preferences and needs. When these concerns are resolved, AI could help to deliver more personalized, participatory, and equitable liver disease care.

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Glucagon-like peptide-1 receptor agonist treatment and risk of esophageal cancer.

Standard GLP-1RA treatment in patients with type 2 diabetes might not decrease the risk of esophageal adenocarcinoma. The validity of the observed decreased risk of esophageal squamous cell carcinoma is uncertain.

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Long-term effectiveness of tenofovir alafenamide versus entecavir in treatment-naïve chronic hepatitis B: A REAL-B study.

BR rates were similar with ETV and TAF, while VR and CR were higher with TAF though the difference was modest (<5% overall, 7-9% in high HBV DNA or ALT groups). Antiviral selection between TAF vs ETV should be based mainly on cost, side effect profile, and patient preference.

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Poor Sensitivity of the Fatty Liver Index Among Lean Individuals.

With its inherent dependence on body-size measures, FLI does not identify lean SLD accurately. Moreover, applying FLI to lean individuals overestimates disease severity. The misclassification and misrepresentation biases imply that FLI should not be used in population-based studies of lean SLD.

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Clin Gastroenterol Hepatol
Healthcare costs in patients according to work ability at celiac disease diagnosis: a nationwide cost-of-illness study.

Patients with impaired work ability at CeD diagnosis face a greater and more persistent economic burden than those with sustained work ability. The over-representation of non-CeD-related healthcare costs among them warrants personalized, multidisciplinary care to mitigate their multifactorial burdens.

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Screening for celiac disease in childhood: cost-effectiveness of multiple genetic and serological testing approaches.

The most cost-effective screening strategy for celiac disease was single-time untargeted serological testing at age 11. The optimal approach is affected by regional factors and may evolve with new evidence. Repeated screening may be preferable for high-risk groups and with high willingness to pay.

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Striated Muscle Contractility and Distal Esophageal Distensibility Define Novel Subtypes of Functional Dysphagia.

A new subtype of FD, termed FD-rED, is proposed. Reduced contraction in the striated muscle region may contribute to reduced esophageal distension in the FD-rED. Focusing on the striated muscle region may provide a promising approach for developing new diagnoses and treatments for FD-rED.

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Endosc Int Open
Clinical feasibility of gastric endoscopic submucosal dissection in patients on glucocorticoids or immunomodulators: Propensity-score-matched study.

In patients receiving GC/IM, gastric ESD was associated with a higher incidence of minor, clinically managed events-chiefly pain and transient fever-whereas major complications remained uncommon. With close monitoring and prompt symptom-directed care, gastric ESD appeared clinically feasible, albeit with slightly greater resource use and observation time.

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Endoscopic stricturotomy for axis-related gastric outlet obstruction following sleeve gastrectomy.

Endoscopic stricturotomy is a promising, minimally invasive treatment for axis-related gastric outlet obstruction post-sleeve gastrectomy. Prospective studies are warranted to confirm long-term outcomes.

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Is size, morphology, site, and access scoring system consistent between endoscopists? Interobserver and intraobserver polyp assessment study.

Morphology was the most consistently scored parameter. Although the SMSA tool remains valuable, efforts such as standardized training and simplification of variable categories may be warranted to improve interobserver consistency and enhance clinical-utility.

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Newly developed plastic stent delivery system for endoscopic ultrasonography-guided gallbladder drainage: Experiments on gallbladder models.

The newly developed PS system prevented bile leakage from the puncture site. The newly developed PS system saved significant time, maintained intra-gallbladder pressure, and prevented bile leakage during the procedure when compared with the current PS system.

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Safety and efficacy of scissor-type knives in colorectal endoscopic submucosal dissection: International multicenter observational study.

Use of scissor-type knives in colorectal ESD outside Japan demonstrated a favorable safety profile. However, certain performance outcomes, such as resection speed and resection success rates, were inferior to Japanese institutions.

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Endoscopy
Assessment of the carbon footprint and cost-effectiveness of endoscopic liquid waste processing methods.

Solidification allows fluids to be safely reallocated to landfill waste and may reduce processing costs and environmental impact. USD appears to be neither environmentally nor economically beneficial for endoscopy units.

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Development of the PROMOTE model to stratify colorectal cancer risk for prioritization of colonoscopy resource use: a multicenter prospective study.

NNS was 8-9 in the high-risk group and 67-71 in the low-risk group across validation cohorts. We developed and validated the PROMOTE model, a simple tool to estimate CRC risk before colonoscopy, to support appropriate referral, optimize prioritization, and improve resource use.

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Gut
<b>CD177</b> <sup>+</sup> <b>neutrophils drive extracellular matrix <b>remodelling</b> and HGF-alpha release in ALPPS-induced liver regeneration</b>.

CD177 + neutrophils drive liver regeneration by promoting endothelial transmigration, ECM degradation and HGF-α release. These findings reveal a neutrophil-mediated mechanism driving surgical liver regeneration and support the potential of CD177 + neutrophil infusion to establish a proregenerative hepatic environment for therapeutic strategies in liver failure.

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Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.

Our findings delineate a circPLCE1/XYLB/Xu5P axis in fibroblasts which orchestrates PPP and fibrogenesis, unveiling a novel therapeutic target for intestinal fibrosis of CD.

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PCK1 deficiency promotes MASH-HCC progression by 12-HETE-induced CD8<sup>+</sup> T cell dysfunction.

This study reveals the pivotal role of the hepatic cell-intrinsic enzyme PCK1 in mediating CD8 + T cell dysfunction via 12-HETE-p38 signalling in MASH-HCC. PCK1 could be a metabolic checkpoint to enhance the efficacy of anti-PD-1 immunotherapy in MASH-HCC.

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Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials.

Approximately one in five asymptomatic FDRs had persistently elevated calprotectin, which was able to differentiate those with presymptomatic CD. The findings highlight calprotectin's utility in identifying at-risk individuals during the potential pre-CD stage for enrolment in prevention trials.

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Spatial transcriptomics defines the molecular progression, invasion and immune landscape of IPMN and IPMN-derived pancreatic cancer.

This study provides a spatially resolved molecular map of IPMN progression, delineating key transcriptomic and immune signatures. These findings advance the understanding of IPMN biology and highlight potential biomarkers for risk stratification and therapeutic strategies.

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Hepatology
An α-specific PI3K inhibitor improves chemotherapy efficacy by inhibiting hepatic stellate cell activation in liver cancer.

This study demonstrates a role of platinum-based chemotherapy on HSC activation in liver cancer. Selective targeting of PI3K p110α may provide a novel strategy to inhibit chemotherapy-induced HSC activation and improve treatment response.

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CXCR6 defines a distinct resident state in γδ T cells for protecting from liver cirrhosis.

Liver-resident CD69⁺CXCR6⁺ γδ T cells constitute a protective immune subset that limit fibrosis development and progression. Enhancing the function or abundance of this population may offer a promising immunotherapeutic strategy for liver cirrhosis.

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Cardiovascular-Kidney-Metabolic syndrome and the risk of liver fibrosis progression and liver-related events in MASLD.

CKM stages are independently associated with the severity and progression of liver fibrosis in MASLD. CKM stage 2 significantly increases liver stiffness progression without excess LRE risk, while CKM stage 3-4 confers the highest risk for liver-related outcomes.

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Myeloid CD36 deficiency alleviates hepatic fibrosis by promoting adaptive immunity of macrophage.

CD36-driven lipid uptake reprograms macrophage metabolism, leading to ferroptosis and impaired adaptive immunity. Targeting CD36 restores macrophage antigen-presenting function and enhances CD8⁺ T cell activation, identifying CD36 as a potential therapeutic target for hepatic fibrosis. The clinical trial was registered in the Research Registry (researchregistry10830).

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Response evaluation to systemic therapy in HCC: Current challenges and future perspectives.

Second, we delve into the challenges of radiological evaluation both in clinical trials and daily practice, with a particular focus on emerging approaches currently under investigation, such as immunotherapy-based downstaging and conversion therapy. Finally, we discuss emerging trends and future directions in radiological assessment techniques, including 3D imaging, artificial intelligence, and radiomics, and their potential impact on refining treatment evaluation in the era of precision oncology.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther
Editorial: Targeting Urgency in IBD-A Historical Divide.

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Clin Gastroenterol Hepatol
Anorectal Manometry and Pelvic Floor Biofeedback Among Transgender Patients Assigned Female at Birth.

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Gastroenterology
Molecular Early Detection for Pancreatic Cancer in High-Risk Individuals: Are We Sure Yet?

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J Hepatol
Acknowledging our reviewers.

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Individualizing endpoints in chronic HBV treatment: HBsAg loss and beyond.

In this expert opinion article, we argue that it is important to shift focus from HBsAg loss as the sole endpoint of HBV trials to a more individualized assessment of response that also considers partial cure (defined as off-treatment sustained low HBsAg with undetectable HBV DNA, potentially combined with other biomarkers) as a favorable treatment outcome. Such a strategy could help increase the number of patients considered responders to treatment, and as such could potentially extend eligibility for novel treatments to more CHB patients who can experience significant benefits.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol
Acral Melanoma With Gastric and Duodenal Metastases Mimicking Blue-Rubber Bleb Nevus Syndrome.

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Appendicovesical Fistula Presenting With Intermittent Passage of Food Residues in Urine.

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Calendar of Courses, Symposiums and Conferences.

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Letter to the Editor.

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Practical Applications of Artificial Intelligence to Improve Efficiency and Reduce Burnout in Gastroenterology and Hepatology Practices.

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Quality Indicators for ERCP.

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When Refractory Crohn's Disease Isn't Crohn's: Ileal Endometriosis.

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Clin Gastroenterol Hepatol
A Rare Case of Multifocal Autoimmune Pancreatitis.

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Bile Duct Compression Due to Rare Vascular Anomaly.

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High heterogeneity of several liver histology parameters in patients with MASLD demonstrated by biopsies from seven segments.

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Internal Hernia and Volvulus After EUS-Guided Gastrojejunostomy.

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Endoscopy
A new method of rendezvous technique - catheter assistance system: report of a video case at balloon-endoscopy-assisted endoscopic retrograde cholangiopancreatography.

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A new treatment: hybrid endoscopic ultrasound guided vascular intervention for huge duodenal varices.

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A novel endoscopic capsule sponge-based technique called transendoscopic sampling for early detection and risk stratification in Barrett's neoplasia.

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A novel peaked cap technique for assisting colonic endoscopic submucosal dissection.

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A novel plastic stent to prevent dislocation after endoscopic ultrasound-guided gallbladder drainage.

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Artificial intelligence in endoscopy: a yet underused but promising tool in underserved settings.

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Barotrauma and delayed perforation upon endoscopic laser ablation of the duodenal mucosa for type 2 diabetes: a case report.

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Calibrated small-caliber-tip transparent hood enables rescue of discontinued colorectal endoscopic submucosal dissection.

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Call for Applications: Endoscopy Junior Editors Board.

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Cholangioscope combined with biliary forceps: a novel double-endoscope traction method for rectal endoscopic submucosal dissection.

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Complete closure of a large gastric defect after endoscopic submucosal dissection by double-layered suturing using wide-opening reopenable clips.

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Diagnosis of jejunal tubular duplication by enteroscopy in an adult female with recurrent gastrointestinal bleeding.

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Endoscopic removal of fractured pancreatic duct stent from side-hole using drill dilator: A troubleshooting case.

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Endoscopic repair of a bronchoesophageal fistula: a dual approach with argon plasma coagulation and clips with anchoring prongs.

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Endoscopic single-scope placement of transendoscopic enteral tubing using a novel traction-assisted method in a child with autism spectrum disorder and refractory constipation.

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Endoscopic ultrasound-guided biliary drainage versus percutaneous transhepatic biliary drainage: adequately designed studies are still needed.

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Endoscopic ultrasound-guided ileocolonic anastomosis for relief malignant bowel obstruction.

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Endoscopy E-Videos - recently published.

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Enhanced submucosal visualization using amber-red color imaging during gel-immersion colorectal endoscopic submucosal dissection.

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One-step removal of nasobiliary tube and pancreatic stent with a new linked-stent approach: a green tip to avoid additional procedure.

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Post-choledochojejunostomy reflux cholangitis due to cholestasis in the blind end of the afferent limb dramatically improved by endoscopic ultrasound-guided gastroenteroscopy.

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Pre-cutting traction-assisted endoscopic submucosal dissection for rectal neuroendocrine tumors.

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Rescue technique using natural orifice transluminal endoscopic surgery for stent migration into the peritoneal cavity during endoscopic ultrasound-guided biliary drainage.

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Successful resection of a subepithelial tumor at the duodenal bulbo-descending junction by endoscopic submucosal excavation.

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Synchronous and histologically heterogeneous multifocal neoplasia detected by confocal laser endomicroscopy in gastric squamous ectopia.

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Toward optimizing the use of limited colonoscopy resource.

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Treatment of colitis cystica profunda via endoscopic submucosal dissection.

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Underwater endoscopic submucosal dissection using a novel extended projection cap for colorectal tumors.

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Gastroenterology
A Gut-Spine Neural Circuit Linking Intrinsic Primary Afferents to Nociceptive Behavior.

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A new dawn break for refractory oral and ileocecal ulcers.

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A rare cause of refractory vomiting and chest pain in an depressive adolescent.

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An Uncommon Cause of Refractory Chronic Diarrhea.

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Prediction and Prevention of Inflammatory Bowel Disease: A Call to Action.

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Turning Gut Sensors into Therapeutic Switches: A Sensorome Roadmap for Metabolic and Gut-Brain Interaction Disorders.

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Gut
"DPP- 4 inhibitor alleviates gut-brain axis Parkinson's disease pathology" - can dipeptidyl peptidase 4 inhibitors be repurposed as disease-modifying drugs for body-first Parkinson's disease patients?

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Cause of chronic diarrhoea.

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Targeting interleukin signalling in liver disease: a new frontier for therapeutic blockade and immunomodulation.

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Tryptophan metabolite indole-3-acetate: a new culprit in irinotecan-induced gut epithelial injury.

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Hepatology
2025 Late Breaking Abstracts.

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Breaching the blood-brain barrier: Functional MRI changes in covert hepatic encephalopathy.

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FIB-4 turns 20: A lesson of serendipity.

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Fellows' Corner.

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Fraction the fat, find the disease: Proton density fat fraction (PDFF) in MASLD diagnosis.

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Letter to the Editor: Beyond Semantics-Acknowledging diagnostic differences between NAFLD and MASLD.

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Letter to the Editor: Clarifying endothelial specificity and hemodynamic coupling of the miR-153-3p-pyroptosis axis.

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Letter to the Editor: Competing risk and surveillance thresholds for HCC in patients with PSC.

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Nuances in POCUS-guided hemodynamic assessment in cirrhosis.

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PSC and HCC: Age and cirrhosis draw the line on risk.

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Reply: Competing risk and surveillance thresholds for HCC in Patients with PSC.

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Response to: Beyond semantics-acknowledging diagnostic differences between NAFLD and MASLD.

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The roadMAP of how terlipressin reverses HRS-AKI.

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J Hepatol
From the Editor's Desk...

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Viral infection as a trigger for primary sclerosing cholangitis in genetically susceptible individuals.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther
Editorial: Targeting Urgency in IBD-A Historical Divide. Authors' Reply.

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Gastrointest Endosc
Anticoagulant antiplatelet agent and proton pump inhibitor use in gastric antral vascular ectasia: a critical consideration in interpreting endoscopic outcomes.

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Balancing patency and reintervention: commentary on suprapapillary plastic stents in unresectable malignant hilar biliary obstruction.

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Challenges in interpreting outcomes of underwater endoscopic submucosal dissection when dual-approach endoscopic submucosal dissection is included.

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Toward personalized patient selection for duodenal mucosal resurfacing in type 2 diabetes.

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Gut
Red cells, red flags: are we harming stable patients with outdated transfusion thresholds?

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Response to 'Rectal versus colonic submucosal cancer rates and procedural outcomes in large non-pedunculated polyps: French ESD registry data'.

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Serum thrombospondin-2 as a non-invasive biomarker for liver fibrosis in chronic hepatitis B.

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J Hepatol
Addressing the Risk of HBV Transmission in Serodifferent Partners.

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Associations of accelerated biological aging with steatotic liver disease and fibrosis.

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Recurrence pattern for HBV-related HCC after liver transplantation in the antiviral era.

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